You (ech01) where right it was a security permission that was not correct. Thanks for the advice.
Just to help other I will give a basic action list how I fixed my problem
1. Select DotNetNuke Folder and right click on "Properties"
2. Select Security Tag and press Advance button
3. In Premissions tab selected the "Replace permission entries"
4. Applied it and wham the it goes
Thank eck01 for giving me direction to my problem.