OK, I've been through this about 6 times, and I'm at my wit's end. I've done this MANY times before with NO issues, and can't understand this. I installed DNN 4.8.2, go through all the "Typical" setup questions, no issues. I'm able to log in as Host. If I go to "Host Settings", I get the error below, as well as any Admin page. BUT if I'm logged in as Admin, the Admin pages work fine. What's going on? This is a brand new, fresh install, fresh (empty) database, emty file directory. I tried upgrading to 4.8.4, same issue. I've been going around and around with 4.9.0 as well, which is different issue. 

Error message I'm getting from "Host Settings":

An error has occurred.
DotNetNuke.Services.Exceptions.PageLoadException: Exception has been thrown by the target of an invocation. ---> System.Reflection.TargetInvocationException: Exception has been thrown by the target of an invocation. ---> System.Security.SecurityException: Request for the permission of type 'System.Security.Permissions.FileIOPermission, mscorlib, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089' failed. at System.Security.CodeAccessSecurityEngine.Check(Object demand, StackCrawlMark& stackMark, Boolean isPermSet) at System.Security.CodeAccessPermission.Demand() at System.Reflection.Assembly.VerifyCodeBaseDiscovery(String codeBase) at System.Reflection.Assembly.get_CodeBase() at System.Web.Handlers.ScriptResourceHandler.GetCodeBaseWithAssert(Assembly assembly) at System.Web.Handlers.ScriptResourceHandler.GetLastWriteTime(Assembly assembly) at System.Web.Handlers.ScriptResourceHandler.GetAssemblyInfoInternal(Assembly assembly) at System.Web.Handlers.ScriptResourceHandler.GetAssemblyInfo(Assembly assembly) at System.Web.Handlers.ScriptResourceHandler.RuntimeScriptResourceHandler.System.Web.Handlers.IScriptResourceHandler.GetScriptResourceUrl(Assembly assembly, String resourceName, CultureInfo culture, Boolean zip, Boolean notifyScriptLoaded) at System.Web.UI.ScriptManager.GetScriptResourceUrl(String resourceName, Assembly assembly) at System.Web.UI.ScriptRegistrationManager.RegisterClientScriptResource(Control control, Type type, String resourceName) at System.Web.UI.ScriptManager.RegisterClientScriptResource(Control control, Type type, String resourceName) The action that failed was: Demand The type of the first permission that failed was: System.Security.Permissions.FileIOPermission The Zone of the assembly that failed was: MyComputer --- End of inner exception stack trace --- at System.RuntimeMethodHandle._InvokeMethodFast(Object target, Object[] arguments, SignatureStruct& sig, MethodAttributes methodAttributes, RuntimeTypeHandle typeOwner) at System.RuntimeMethodHandle.InvokeMethodFast(Object target, Object[] arguments, Signature sig, MethodAttributes methodAttributes, RuntimeTypeHandle typeOwner) at System.Reflection.RuntimeMethodInfo.Invoke(Object obj, BindingFlags invokeAttr, Binder binder, Object[] parameters, CultureInfo culture, Boolean skipVisibilityChecks) at System.Reflection.RuntimeMethodInfo.Invoke(Object obj, BindingFlags invokeAttr, Binder binder, Object[] parameters, CultureInfo culture) at System.RuntimeType.InvokeMember(String name, BindingFlags bindingFlags, Binder binder, Object target, Object[] providedArgs, ParameterModifier[] modifiers, CultureInfo culture, String[] namedParams) at System.Web.UI.WebControls.ValidatorCompatibilityHelper.RegisterClientScriptResource(Control control, Type type, String resourceName) at System.Web.UI.WebControls.BaseValidator.RegisterValidatorCommonScript() at System.Web.UI.WebControls.BaseValidator.OnPreRender(EventArgs e) at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Control.PreRenderRecursiveInternal() at System.Web.UI.Page.ProcessRequestMain(Boolean includeStagesBeforeAsyncPoint, Boolean includeStagesAfterAsyncPoint) --- End of inner exception stack trace ---

Please help!

Thanks!

Tom