I checked the log, and it doesn't look like the requests are even getting to the smtp server.
I also checked the email addresses, no problem there. Changing the host address to my gmail account works. However the same gmail account used as the "from " in a newsletter doesn't work.
Something interesting, on the same server I have a 4.5.0 DNN site, and the newsletter functionality works there. I tried a 4.6.0 site and that doesn't work. I recently made some changes to my schedulers to increase performance. Would I have stopped some kind of process that the email requires?