Hi MHullinger,
I'm not sure exactly what skin you're referring to here. If it's just a simple change on a single installation, you might be able to get away with editing the skin.css file. You can find this file in the Portals/[PortalId]/Skins/[SkinName]/ subdirectory, where [PortalId] is the portal number that the skin is stored under (and "_Default" if it's installed for all portals), and [SkinName] is the name of the skin.
So for the DNN-Blue skin, installed for all portals, you'd look in this directory: \Portals\_default\Skins\DNN-Blue
For many small changes, you can just tweak the classes defined in this file.
Hope this points you in the right direction!
Brandon