Add me to the list of users experiencing the problem. I am running 4.7 and on an Intranet - so an outside site hitting the site is not possible. I have 1 web/db server with 4 child portals running (parent portal not used). It has been running for two years, mostly under a 3.x version but upgraded it a few months ago to 4.X. It seems to happen to fresh as well as old installs of DNN.
Here is what I have done in the past week to hopeful get rid of the problem:
First Occurance
1) Turned off IIS logging - Extended Logging was ON
2) Moved 3GBs of IIS log files into a subfolder
6 Days later it happened again
1) Defragged the HD's
2) Added and Indexes and Statistics to my custom module tables
3) Altered 1 record from -1 to 0 in the DesktopModules to Module MarketPlace
4) Refreshed all my existing stats and indexs in the database.
3 Days later it happened again
1) Changed Host Settings to NO CACHE
UPDATE: It hasnt happend for 2 weeks now!!
I will post back here if it happens again and or I figure out the solution. Time will tell.